Fluphenazine hydrochloride

Pronunciation

Definition 1

A drug that is used to treat mental and emotional disorders and is being studied in the treatment of multiple myeloma. Fluphenazine hydrochloride may stop tumor growth by keeping myeloma cells from dividing and causing them to die. It is a type of antipsychotic. Also called fluphenazine. (NCI Dictionary)

Definition 2

The hydrochloride salt of fluphenazine, a phenothiazine with antipsychotic activity and potential antineoplastic activity. Fluphenazine blocks postsynaptic dopamine D2 receptors in the limbic system, cortical system and basal ganglia, resulting in a reduction of schizophrenia-associated hallucinations and delusions. In addition, as a serotonin antagonist, this agent may inhibit lymphocyte and myeloma cell proliferation by blocking 5-hydroxytrptamine type 1B (5-HT type 1B) receptors for serotonin. (NCI Thesaurus)

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