Fms/Trk Tyrosine Kinase Inhibitor PLX7486 Tosylate

The tosylate salt form of PLX7486, a selective inhibitor of the receptor tyrosine kinases colony-stimulating factor-1 receptor (CSF1R; fms) and neurotrophic tyrosine kinase receptor types 1, 2 and 3 (TrkA, TrkB, and TrkC, respectively) with potential antineoplastic activity. Upon administration, PLX7486 binds to and inhibits the activity of these tyrosine kinases. This inhibits Fms and Trk-mediated signaling transduction pathways that are upregulated in certain cancer cell types. This may eventually halt tumor cell proliferation in Fms and TrkA, TrkB, and/or TrkC-overexpressing tumor cells. Fms and TrkA, TrkB, and TrkC are receptor tyrosine kinases that are upregulated or mutated in a variety of tumors and promote tumor cell proliferation and survival. (NCI Thesaurus)

YOU MAY ALSO LIKE

Fms-Related Tyrosine Kinase 3

Fms-related receptor tyrosine kinase; growth factor receptor for hematopoietic stem and progenitor cells.

FMS Inhibitor JNJ-40346527

A small molecule and orally available inhibitor of colony-stimulating factor-1 receptor (CSF1R; FMS) with potential antineoplastic activity. FMS tyrosine kinase inhibitor JNJ-40346527…

FMR1 wt Allele

Human FMR1 wild-type allele is located in the vicinity of Xq27.3 and is approximately 39 kb in length. This allele, which encodes…

FMR1 Gene

This gene may be involved in the regulation of mRNA trafficking.

FMOD wt Allele

Human FMOD wild-type allele is located in the vicinity of 1q32 and is approximately 11 kb in length. This allele, which encodes…

FMOD Gene

This gene may play a role in the assembly of the extracellular matrix.