| Health / Medical Topics |
Folate Receptor Targeted Epothilone BMS753493
A folate receptor-targeting antimitotic agent with potential antineoplastic activity. Folate receptor-targeted epothilone BMS753493 contains an epothilone moiety linked to a single folate molecule. Mediated through the folate moiety, this agent delivers the antimitotic epothilone component into cells expressing folic acid receptors, frequently upregulated in many types of tumor cells. After ligand-receptor internalization, the epothilone moiety induces microtubule polymerization and stabilizes microtubules against depolymerization, resulting in the inhibition of mitosis and cellular proliferation. (NCI Thesaurus)
YOU MAY ALSO LIKE
Folate receptor beta (255 aa, ~29 kDa) is encoded by the human FOLR2 gene. This protein is involved in folic acid…
Encoded as 2 alternative isoforms by human FOLR1 Gene (FOLR Family), high affinity Folate Receptor 1 is a protein with eight disulfide…
Total folate activity which adjusts for the lower bioavailability of folate in food compared to folic acid using an accepted conversion…
A cancer vaccine comprised of human leukocyte antigen (HLA) A2 restricted folate binding protein (FBP) epitope E39 (amino acids 191 to 199),…
A type of drug that stops cells from using folic acid to make DNA and may kill cancer cells. Certain folate antagonists…
A nutrient in the vitamin B complex that the body needs in small amounts to function and stay healthy. Folate helps to…
