Health / Medical Topics

    Folate Receptor-Targeted Tubulysin Conjugate EC1456

    An injectable targeted small molecule drug conjugate (SMDC) consisting of folate (vitamin B9) covalently linked to the potent mitotic poison and cytotoxic agent, tubulysin B hydrazide (Tub-B-H) with potential antineoplastic activity. Upon administration, the folate moiety of folate receptor-targeted tubulysin conjugate EC1456 preferentially binds to tumor cells expressing folate receptors (FR). After binding to FR, the agent is internalized by tumor cells and the Tub-B-H moiety inhibits the polymerization of tubulin into microtubules. This may lead to both cell cycle arrest and tumor cell apoptosis. FR, the membrane-bound, high-affinity receptor for folate, is overexpressed on a wide range of primary and metastatic human cancers. (NCI Thesaurus)




    YOU MAY ALSO LIKE

    A folate receptor-targeting radiopharmaceutical consisting of a folate-containing tetrapeptide chelator to which technetium Tc 99m is linked. The folate component of folate…
    A folate receptor-targeting antimitotic agent with potential antineoplastic activity. Folate receptor-targeted epothilone BMS753493 contains an epothilone moiety linked to a single folate…
    Folate receptor beta (255 aa, ~29 kDa) is encoded by the human FOLR2 gene. This protein is involved in folic acid…
    Encoded as 2 alternative isoforms by human FOLR1 Gene (FOLR Family), high affinity Folate Receptor 1 is a protein with eight disulfide…
    Total folate activity which adjusts for the lower bioavailability of folate in food compared to folic acid using an accepted conversion…
    A cancer vaccine comprised of human leukocyte antigen (HLA) A2 restricted folate binding protein (FBP) epitope E39 (amino acids 191 to 199),…

    © 1991-2023 The Titi Tudorancea Bulletin | Titi Tudorancea® is a Registered Trademark | Terms of use and privacy policy
    Contact