| Health / Medical Topics |
Fotemustine
Pronunciation
Definition 1
A substance being studied in the treatment of brain tumors and metastatic melanoma of the eye. It is a type of nitrosourea. (NCI Dictionary)
Definition 2
A chloroethylating nitrosourea with antineoplastic activity. Fotemustine alkylates guanine by forming chloroethyl adducts at the 6 position of guanine, resulting in N1-guanine and N3-cytosine cross linkages, inhibition of DNA synthesis, cell cycle arrest, and finally apoptosis. This agent is lipophilic and crosses the blood-brain barrier. (NCI Thesaurus)
YOU MAY ALSO LIKE
An anti-tumor antibiotic isolated from the bacterium Streptomyces pulveraceus. Fostriecin inhibits topoisomerase II catalytic activity, resulting in impaired DNA and RNA synthesis…
Unrelated persons who are part of the same foster family.
The anhydrous form of fostamatinib disodium, an orally available Syk kinase inhibitor with potential anti-inflammatory and immunomodulating activities. Fostamatinib inhibits Syk kinase-mediated…
A substance being studied in the treatment of cancer and certain other diseases, such as rheumatoid arthritis. It may block tumor cell…
A small molecule Syk kinase inhibitor with potential anti-inflammatory and immunomodulating activities. Fostamatinib inhibits Syk kinase-mediated IgG Fc gamma receptor signaling, resulting…
A sample of air that preserves the composition of the environment at the time it was deposited. Bubbles found in ice cores…
