Health / Medical Topics

    G Protein-Coupled Receptor 54

    Definition 1

    G protein-coupled receptor 54 protein (395, 43 kD) is a cell communication process protein that is encoded by the human GPR54 gene and has a role in the G protein-coupled receptor signaling pathway. (NCI Thesaurus)

    Definition 2

    Encoded by human GPR54 Gene, 395-aa 43-kDa G Protein-Coupled Receptor 54 is a Gq/11-coupled receptor for endogenous KISS1 (Metastin), which appears to inhibit chemotaxis. (NCI Thesaurus)

    Definition 3

    G Protein-Coupled Receptor 54, encoded by the GPR54 gene, is a G protein-coupled receptor. The endogenous ligand of this protein is the KISS1 protein. The truncated form of KISS1, metastin, inhibits chemotaxis and invasion of GPR54-transfected CHO cells in vitro and attenuates pulmonary metastasis of GPR54-transfected B16-BL6 melanomas in vivo. (from OMIM 604161) (NCI Thesaurus)




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