G-Quadruplex Stabilizer BMVC

A carbazole derivative (3,6-bis[2-(1-methylpyridinium)vinyl]carbazole diiodide) that selectively targets to the G-quadruplex DNA structure, used as a fluorescent probe for cancer cytological diagnosis and with potential antitumor activity. G-quadruplex stabilizer BMVC, preferentially uptaken by cancer cells, binds to and stabilize the telomeric G-quadruplex structure at the end of DNA; when visualized with fluorescent imaging device, BMVC emits bright fluorescent light and can be used to differentiate tumor cells from normal cells. The BMVC/G-quadruplex complexes also interfere with the activity of telomerase, which is highly active in tumor cells and plays a key role in tumorigenesis while expressed at very low levels in most somatic cells. (NCI Thesaurus)

YOU MAY ALSO LIKE

G-Protein Signaling Pathway

G-aS-coupled receptors stimulate adenylyl cyclase (AC), which synthesizes cAMP from ATP. In contrast Gai-coupled receptors inhibit AC and so reduce cAMP…

G-Protein Coupled Receptor 56

G-protein coupled receptor 56 (693 aa, ~78 kDa) is encoded by the human GPR56 gene. This protein is involved in intercellular…

G-Protein Coupled Receptor 183

G-protein coupled receptor 183 (361 aa, ~41 kDa) is encoded by the human GPR183 gene. This protein is involved in both B-cell…

G-Protein Coupled Receptor 120

G-protein coupled receptor 120 (377 aa, ~42 kDa) is encoded by the human GPR120 gene. This protein plays a role in fatty…

G-Protein Coupled Estrogen Receptor 1

G-protein coupled estrogen receptor 1 (375 aa, ~42 kDa) is encoded by the human GPER gene. This protein plays a role in…

G-CSF

A colony-stimulating factor that stimulates the production of neutrophils (a type of white blood cell). It is a cytokine that is a…