Galiximab

Pronunciation

Definition 1

A substance being studied in the treatment of follicular non-Hodgkin lymphoma. It binds to the protein CD80, which is found on certain normal white blood cells and on white blood cells that are cancer. It is a type of monoclonal antibody. (NCI Dictionary)

Definition 2

A chimeric IgG1 monoclonal antibody directed against CD80, the natural ligand for the T-cell antigen CD28 which mediates T-cell and B-cell adhesion. Galiximab binds to CD80 expressed on the cell surfaces of follicular lymphomas, resulting in antibody-dependent cell-mediated cytotoxicity (ADCC). CD80 is expressed on activated B-cells and gamma-interferon-stimulated monocytes and is often expressed at low levels on the surfaces of follicular lymphoma cells and other lymphoid malignancies. (NCI Thesaurus)

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