| Health / Medical Topics |
Gamma-Glutamylcysteine Synthetase Inhibitor
Any substance that inhibits glutamate-cysteine ligase (gamma-glutamylcysteine synthetase), an enzyme that catalyzes the ATP-dependent condensation of cysteine and glutamate to form the dipeptide gamma-glutamylcysteine, the rate-limiting step in the biosynthesis of glutathione. Since glutathione is critical in protecting cells against oxidative stress, its depletion results in free radical-induced apoptosis. (NCI Thesaurus)
YOU MAY ALSO LIKE
Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits,…
GGT participates in the transfer of amino acids across the cellular membrane and in glutathione metabolism. High concentrations are found in the…
Gamma-glutamyl hydrolase (318 aa, ~36 kDa) is encoded by the human GGH gene. This protein is involved in the hydrolysis of gamma-linked…
Gamma-enolase (434 aa, ~47 kDa) is encoded by the human ENO2 gene. This protein is involved in glycolysis, neurotrophy and neuroprotection. …
An orally available nutritional supplement containing the gamma and delta forms of the vitamin E family member tocotrienol, with hypocholesterolemic, antithrombotic, antioxidant,…
Gamma-aminobutyric acid type B receptor subunit 2 (941 aa, ~106 kDa) is encoded by the human GABBR2 gene. This protein plays a…
