Health / Medical Topics |
GATA2 wt Allele
Human GATA2 wild-type allele is located in the vicinity of 3q21.3 and is approximately 14 kb in length. This allele, which encodes endothelial transcription factor GATA-2 protein, plays a role in both transcriptional regulation and DNA binding. Mutation or aberrant expression of the gene is associated with myelodysplasic syndrome, chronic myeloid leukemia and aplastic anemia. (NCI Thesaurus)
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