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Glucose-6-Phosphate Isomerase
Definition 1
Glucose-6-phosphate isomerase (558 aa, ~63 kDa) is encoded by the human GPI gene. This protein is involved in glycolysis in as a cytoplasmic homodimer and has a secreted monomeric form that either exhibits cytokine activity or can function as a neurotrophic factor. (NCI Thesaurus)
Definition 2
A member of the class of cytokines secreted by tumor cells. It elicits increases in cell motility and phosphoinositide metabolism in the secreting or producing cell via a pertussis toxin-sensitive G-protein signal transduction pathway. The factor has also been used as a marker for bladder cancer. (NLM, Medical Subject Headings)
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