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Glycinamide ribonucleotide formyltransferase inhibitor
Pronunciation
Definition 1
A drug that blocks DNA synthesis and may prevent tumor growth. It is being studied as a treatment for cancer. (NCI Dictionary)
Definition 2
Any substance that inhibits glycinamide ribonucleotide formyltransferase, the first folate dependent enzyme in de novo purine synthesis. Inhibition of glycinamide ribonucleotide formyltransferase causes purine depletion and results in inhibition of DNA synthesis and cell cycle arrest. (NCI Thesaurus)
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