Golotimod

An orally bioavailable synthetic peptide containing the amino acids D-glutamine and L-tryptophan connected by a gamma-glutamyl linkage with potential immunostimulating, antimicrobial and antineoplastic activities. Although the exact mechanism of action is unknown, golotimod appears to inhibit the expression of STAT-3, reversing immunosuppression and stimulating an anti-tumor immune response. This agent may stimulate the production of T-lymphocytes, in particular the helper T (Th1) cells, activate macrophages, and increase levels of interleukin 2 and interferon gamma. STAT-3, a transcription factor upregulated in many cancer cell types, is involved in tumor cell growth and survival and immunosuppression. (NCI Thesaurus)

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GOLM1 wt Allele

Human GOLM1 wild-type allele is located in the vicinity of 9q21.33 and is approximately 74 kb in length. This allele, which encodes…

GOLM1 Gene

This gene is involved in both the trafficking and posttranslational modification of proteins.

Golimumab

A human monoclonal antibody directed against the pro-inflammatory cytokine tumor necrosis factor-alpha (TNF-a) with immunosuppressive activity. Golimumab binds to TNF-a, thereby preventing…

GOLIM4 wt Allele

Human GOLIM4 wild-type allele is located in the vicinity of 3q26.2 and is approximately 87 kb in length. This allele, which encodes…

GOLIM4 Gene

This gene plays a role in protein targeting.