GRB2-Associated Binding Protein 2

GRB2-Associated Binding Protein 2 (GAB2), encoded by the human GAB2 gene, is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Upon tyrosine phosphorylation, GAB2 interacts with SHP2 tyrosine phosphatase and GRB2 adapter protein. It is the limiting component of the GAB2-SHP2 complex, signaling Erk MAP kinase activation and terminal differentiation of K562 CML cells. GAB2 also has an inhibitory effect on the activation of ELK1-dependent transcription triggered by a dominant active Ras mutant or under growth factor stimulation. Two alternatively spliced transcripts encode different isoforms and the short isoform is the main isoform. This protein is overexpressed and estrogen regulated in human breast cancer. (From LocusLink, OMIM and NCI) (NCI Thesaurus)

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