GRB2-Related Adaptor Protein

This protein is a member of the GRB2/Sem5/Drk family. It functions as a cytoplasmic signaling protein which contains an SH2 domain flanked by two SH3 domains. The SH2 domain interacts with ligand-activated receptors for stem cell factor and erythropoietin, and facilitates the formation of a stable complex with the BCR-ABL oncoprotein. This protein also associates with the Ras guanine nucleotide exchange factor SOS1 (son of sevenless homolog 1) through its N-terminal SH3 domain. Expression is restricted to lymphoid tissues. (NCI Thesaurus)

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GRB2-Associated-Binding Protein 1

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GRB2-Associated Binding Protein 2

GRB2-Associated Binding Protein 2 (GAB2), encoded by the human GAB2 gene, is the principal activator of phosphatidylinositol-3 kinase in response to activation…

GRB2 wt Allele

Human GRB2 wild-type allele is located within 17q24-q25 and is approximately 88 kb in length. This allele, which encodes growth factor receptor-bound…

GRB2 Protein

An adaptor protein which bridges cell surface tyrosine kinase receptors with downstream signal transmitters such as ras p21. (from IRB Summaries) …

GRB2 Gene

This gene plays a role in signal transduction and intercellular signaling.

GRB14 wt Allele

Human GRB14 wild-type allele is located within 2q22-q24 and is approximately 129 kb in length. This allele, which encodes growth factor receptor-bound…