| Health / Medical Topics |
Growth Factor Receptor-Bound Protein 10
Grb10 belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. It interacts with IGF1R, PDGFRB, and EGFR and binds to the Raf-1 and MEK1 kinases. Its cellular role is still unclear and a positive as well as an inhibitory role in mitogenesis depending on the cell context has been implicated. Grb10 may regulate signaling between plasma membrane receptors and the apoptosis-inducing machinery on the mitochondrial outer membrane. (from LocusLink, J Biol Chem 1999;274:35719-24, and Mol Cell Biol 1999;19:6217-28) (NCI Thesaurus)
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