Growth Hormone Receptor

Widely expressed by human GHR Gene (Cytokine Receptor I Subfamily 1), Growth Hormone Receptor is a type I membrane receptor for growth hormone with a ligand-binding extracellular domain (GHBP); a FnIII domain; a WSXWS motif; a cytoplasmic UbE motif for ubiquitination and internalization; and a cytoplasmic JAK interaction box 1 motif. Produced by cleavage by cell surface ADAM17, secreted GHBP may modulate GH signaling; GH appears to inhibit ADAM17. Tyr phosphorylated on GH binding by JAK2, homodimerized GHR appears to activate JAK2/STAT pathways that produce IGF1, which activates mitogenic and anabolic growth responses. SOCS3 may inhibit JAK2 activation while CIS and SOCS2 may inhibit STAT5 activation by GHR. GHR defects cause Laron dwarfism and idiopathic short stature. (NCI Thesaurus)

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Growth Hormone Measurement

The determination of the amount of growth hormone (GH) present in a sample.

Growth Hormone Inhibiting Hormone Measurement

The determination of the amount of growth hormone inhibiting hormone present in a sample.

Growth Hormone Excess

Overproduction of growth hormone, a protein-based peptide that stimulates growth, cell reproduction, and cell regeneration.

Growth Hormone Deficiency

Insufficient production of growth hormone.

Growth hormone

A protein made by the pituitary gland that helps control body growth and the use of glucose and fat in the…

Growth Failure

Less than normal linear growth in an infant or child.