Health / Medical Topics |
Guaifenesin/Codeine
A combination preparation containing guaifenesin and the opioid agonist codeine with expectorant and antitussive activities, respectively. Guaifenesin works by drawing water into respiratory tracts, by which reducing adhesiveness and surface tension of mucus as well as increasing hydration of mucus, thereby reducing the viscosity of mucus and making cough more productive. Codeine, a naturally occurring phenanthrene alkaloid and opioid agonist mimics the actions of opioids by binding to the opioid receptors at many sites within the central nervous system (CNS), thereby also suppressing the cough reflex by activating receptors in the cough center. (NCI Thesaurus)
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