Library / English Dictionary

GUANINE

Pronunciation (US):

(GB):

 I. (noun) 

Sense 1

Meaning:

A purine base found in DNA and RNA; pairs with cytosine

Synonyms:

G; guanine

Classified under:

Nouns denoting substances

Hypernyms ("guanine" is a kind of...):

purine (any of several bases that are derivatives of purine)

Holonyms ("guanine" is a substance of...):

deoxyribonucleic acid; desoxyribonucleic acid; DNA ((biochemistry) a long linear polymer found in the nucleus of a cell and formed from nucleotides and shaped like a double helix; associated with the transmission of genetic information)

ribonucleic acid; RNA ((biochemistry) a long linear polymer of nucleotides found in the nucleus but mainly in the cytoplasm of a cell where it is associated with microsomes; it transmits genetic information from DNA to the cytoplasm and controls certain chemical processes in the cell)

Credits

 Context examples: 

RAS is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase-activating protein.

(Oncogene N-RAS, NCI Thesaurus)

Cactinomycin binds to DNA by intercalating between guanine and cytosine, forming stable antibiotic-DNA complexes that inhibit RNA and protein synthesis.

(Cactinomycin, NCI Thesaurus)

This allele, which encodes Rho guanine nucleotide exchange factor 12 protein, is involved in the modulation of signaling that is mediated by both Rho-family GTPases or G-protein coupled receptors.

(ARHGEF12 wt Allele, NCI Thesaurus)

This allele, which encodes Rho guanine nucleotide exchange factor 2 protein, plays a role in signaling, apoptosis, and cell proliferation.

(ARHGEF2 wt Allele, NCI Thesaurus)

This allele, which encodes Rho guanine nucleotide exchange factor 1 protein, is involved in the regulation of G protein coupled receptor signal transduction.

(ARHGEF1 wt Allele, NCI Thesaurus)

This protein is involved in the propagation of intracellular signaling through guanine nucleotide exchange activity.

(Phosphatidylinositol 3,4,5-Trisphosphate-Dependent Rac Exchanger 1 Protein, NCI Thesaurus)

Piperazinedione alkylates DNA at the N-7 position of guanine, inhibiting DNA replication and inducing cell cycle arrest.

(Piperazinedione, NCI Thesaurus)

This allele, which encodes rho guanine nucleotide exchange factor 7 protein, is involved in the regulation of both GTPase-mediated signaling and apoptosis.

(ARHGEF7 wt Allele, NCI Thesaurus)

This allele, which encodes Rho guanine nucleotide exchange factor 5 protein, plays a role in both Rho signal transduction and cytoskeletal organization.

(ARHGEF5 wt Allele, NCI Thesaurus)

This protein interfaces the B-cell receptor-associated SYK tyrosine kinase with PLC-gamma, the VAV guanine nucleotide exchange factor, and the GRB2 and NCK adaptor proteins.

(B-Cell Linker, NCI Thesaurus)