Guanine Nucleotide-Binding Protein G(I)/G(S)/G(T) Subunit Beta-3

Encoded by human GNB3 Gene, 340-aa 37-kDa Guanine Nucleotide Binding Protein Beta 3 is a heterotrimeric G protein beta subunit with 7 WD repeats and involved in transmembrane signaling as a transducer that regulates G protein alpha subunits and integrates signals between receptors and effector proteins. The G protein beta and gamma subunits are required for GTPase activity, for GTP replacement of GDP, and for G protein/effector interaction. A splicing polymorphism is associated with essential hypertension and obesity. (NCI Thesaurus)

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