HDAC6 wt Allele

Human HDAC6 wild-type allele is located in the vicinity of Xp11.23 and is approximately 23 kb in length. This allele, which encodes histone deacetylase 6 protein, is involved in the deacetylation of lysine residues on the N-terminal region of the core histones H2A, H2B, H3 and H4. It also plays a role in the deacetylation of tubulin. (NCI Thesaurus)

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HDAC6 Inhibitor ACY-1215

An orally bioavailable, specific inhibitor of histone deacetylase 6 (HDAC6) with potential antineoplastic activity. ACY-1215 selectively targets and binds to HDAC6, thereby…

HDAC6 Gene

This gene is involved in chromatin remodeling, repression of gene expression and cellular management of misfolded protein-induced stress.

HDAC5 wt Allele

Human HDAC5 wild-type allele is located within 17q21 and is approximately 47 kb in length. This allele, which encodes histone deacetylase 5…

HDAC5 Gene

This gene plays a role in chromatin remodeling, repression of gene expression and control of cellular differentiation.

HDAC4 wt Allele

Human HDAC4 wild-type allele is located in the vicinity of 2q37.2 and is approximately 352 kb in length. This allele, which encodes…

HDAC4 Gene

This gene is involved in chromatin remodeling, repression of gene expression and myoblast differentiation.