| Health / Medical Topics |
Heat Shock 27 kD Protein 1
Heat-shock proteins belong to a large group stress proteins, induced in response to environmental challenges and developmental transitions. Involved in stress resistance and actin organization, synthesis of HSP27 is correlated with the acquisition of thermotolerance. HSP27 belongs to the HSP20 family and shows sequence similarity to alpha-crystallins. Cytoplasmic HSP27 associates with alpha- and beta-tubulin, and with interphase and mitotic microtubules. HSP27 translocates to the nucleus during heat shock and is phosphorylated on exposure to PKC activators and heat shock. (from OMIM 602195, Swiss-Prot P04792, and NCI) (NCI Thesaurus)
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