| Health / Medical Topics |
Heavy Chain Disease
One of a group of rare disorders of immunoglobulin synthesis associated with B-cell proliferative disorders and diagnosed by the finding of heavy chains in the serum, urine, or both. Heavy chains are immunologically related to the Fc fragment of the immunoglobulin chain. Three types of heavy chain disease (HCD) have been recognized: gamma heavy chain disease (associated with Waldenstrom's macroglobulinemia), alpha heavy chain disease (also known as immunoproliferative small intestinal disease or Mediterranean lymphoma), and mu heavy chain disease (associated with chronic lymphocytic leukemia). Complications of HCD vary depending upon type. (NCI Thesaurus)
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