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HELPER T CELL
I. (noun)
Sense 1
Meaning:
T cell with CD4 receptor that recognizes antigens on the surface of a virus-infected cell and secretes lymphokines that stimulate B cells and killer T cells; helper T cells are infected and killed by the AIDS virus
Synonyms:
CD4 cell; CD4 T cell; helper cell; helper T cell
Classified under:
Hypernyms ("helper T cell" is a kind of...):
T cell; T lymphocyte (a small lymphocyte developed in the thymus; it orchestrates the immune system's response to infected or malignant cells)
Context examples:
This allele, which encodes hepatitis A virus cellular receptor 2 protein, is involved in the activation of macrophages and helper T cells.
(HAVCR2 wt Allele, NCI Thesaurus)
T cells, especially helper T cells, are a key part of the adaptive immune system.
(Rapid-response immune cells are fully prepared before invasion strikes, NIH)
This may enhance recognition of tumors by the immune system, and activate both cytotoxic CD8+ T cells and CD4+ helper T cells against tumor cells.
(Autologous Tumor Cell Proteoliposome Chronic Lymphocytic Leukemia Vaccine, NCI Thesaurus)
Therefore, alphaDC1 has a much more significant capability of inducing helper T cell (CD4+ T-cell) responses in comparison with the "gold standard" DCs.
(Alpha-type-1 Polarized Dendritic Cells, NCI Thesaurus)
Peptide MHC Complexes consist of proteolytically-processed low molecular weight amino acid fragments of antigenic foreign proteins noncovalently bound to self MHC antigens and displayed on the surface of antigen presenting macrophages to helper T cells as an important part of an immune response.
(Peptide/MHC Complex, NCI Thesaurus)
CD200 is a type 1a transmembrane protein, related to the B7 family of co-stimulatory receptors, and is upregulated on the surface of multiple hematologic malignant cells; this transmembrane protein appears to be involved in the downregulation of a Th1 (helper T cell) immune response.
(Anti-CD200 Monoclonal Antibody ALXN6000, NCI Thesaurus)
Upon intradermal administration into the patient, the mature LCs may activate cell-mediated immunity and induce both cytotoxic CD8+ T cells and CD4+ helper T cells against cancer cells expressing CT7, MAGE-A3 and WT1 tumor antigens.
(Autologous CT7/MAGE-A3/WT1 mRNA-Electroporated Langerhans-Type Dendritic Cells, NCI Thesaurus)
Upon administration of bivalent HPV16/18 therapeutic cervical cancer vaccine, the expressed proteins may activate cell-mediated immunity and induce both cytotoxic CD8+ T cells and CD4+ helper T cells against the target antigens HPV16-E7 and HPV18-E7, which leads to HPV viral clearance.
(Bivalent HPV16/18 Therapeutic Cervical Cancer Vaccine, NCI Thesaurus)
De-immunization involves the modification of potential helper T cell epitopes that bind to MHC class II molecules; humanization involves combining recombinant murine variable (V) regions with human immunoglobulin light and heavy chain constant regions.
(DI-Leu16-IL2 Immunocytokine, NCI Thesaurus)
Also called helper T cell.
(CD4-positive T lymphocyte, NCI Dictionary)
