Heparin Binding Growth Factor

Exhibiting high affinity for heparin, Heparin-Binding Growth Factors (HBGF) control proliferation and differentiation of mesenchymal, epithelial, and neuroectodermal cells. Heparin may store some growth factors in the extracellular matrix, stabilize these proteins, and protect them. For some factors, heparin binding is essential to interact with receptors; it enhances the activity of some HBGF. Class 1 factors comprise acidic proteins, related to (acidic) aFGF. Class 2 factors comprise basic proteins, related to (basic) bFGF. HBGFs appear to be products of different genes; some may not be mitogenic or secreted. Current members include FGF-1, FGF-2, FGF-3, FGF-4, FGF-5, FGF-6, FGF-7, FGF-8, FGF-9, FGF-10, FGF-11, FGF-12, FGF-13, FGF-14, FGF-15, FGF-16, FGF-17, FGF-18, FGF-19, FGF-20, FGF-21, FGF-22, and FGF-23. (NCI Thesaurus)

YOU MAY ALSO LIKE

Heparin Binding

Heparin Binding involves a biophysical interaction between a biological molecule, such as a protein, and heparin, a sulfated glycosaminoglycan of mixed polysaccharide…

Heparin

A substance that slows the formation of blood clots. Heparin is made by the liver, lungs, and other tissues in the body…

Heparanase-2

Heparanase-2 (592 aa, ~67 kDa) is encoded by the human HPSE2 gene. This protein is involved in the proteolysis of heparan sulfate…

Heparanase

Heparanase (543 aa, ~61 kDa) is encoded by the human HPSE gene. This protein plays a role in proteoglycan catabolism.

Heparan-Sulfate 6-O-Sulfotransferase 2

Heparan-sulfate 6-O-sulfotransferase 2 (605 aa, ~69 kDa) is encoded by the human HS6ST2 gene. This protein plays a role in the sulfation…

Heparan Sulfate Proteoglycan

Heparan Sulfate Proteoglycan is an extracellular matrix and vascular basal lamina component. Heparan Sulfate is also an essential co-factor in cell-matrix adhesion…