| Health / Medical Topics |
Her2/erbb2/neu Staining Method
A immunohistochemical technique to identify ErbB2/Neu gene, which encodes for 185-kDa member of the ErbB family of cell surface receptor tyrosine kinases. This family of growth factor receptors is comprised of four members: epidermal growth factor receptor (also termed ErbB1/HER1), ErbB2/Neu/HER2/p185, ErbB3/HER3, and ErbB4/HER4. Activation of the ErbB family of growth factor receptors and subsequent stimulation of their associated intracellular signaling pathways is a significant factor in the genesis of several human cancers. The technique is used in diagnostic histopathology to identify breast cancer. (NCI Thesaurus)
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