Hexadecyloxypropyl Cidofovir

An alkoxyalkyl ester prodrug containing the synthetic, acyclic nucleoside monophosphate analog cidofovir linked, through its phosphonate group, to a lipid, 3-hexadecyloxy-1-propanol, with antiviral activity against double-stranded DNA viruses. Upon oral administration, hexadecyloxypropyl-cidofovir crosses the intestinal wall and penetrates target viral-infected cells before being cleaved to the free antiviral agent cidofovir. In turn, cidofovir is phosphorylated by pyruvate kinases to its active metabolite cidofovir diphosphate. Cidofovir diphosphate, bearing structural similarity to nucleotides, competes with deoxycytosine-5-triphosphate (dCTP) for viral DNA polymerase and gets incorporated into the growing viral DNA strands. As a result, it prevents further DNA polymerization and disrupts DNA replication of viruses. Compared to cidofovir, which is given intravenously, hexadecyloxypropyl-cidofovir shows better oral bioavailability, less toxicity and enhanced cellular penetration. (NCI Thesaurus)

YOU MAY ALSO LIKE

Hexadecenoic Acid trans

A class of monounsaturated fatty acids with 16 carbons and the double bond in the trans formation.

Hexadecenoic Acid cis

A class of monounsaturated fatty acids with 16 carbons and the double bond in the cis formation.

Hexadecenoic Acid

A class of monounsaturated fatty acids with 16 carbons.

Hexadecatrienoic Acid n-4

A polyunsaturated long-chain fatty acid with a 16-carbon backbone and 3 double bonds originating from the 4rd, 7th and 10th positions from…

Hexadecatrienoic Acid n-3

A polyunsaturated long-chain fatty acid with a 16-carbon backbone and 3 double bonds originating from the 3rd, 6th and 9th positions from…

Hexadecatrienoic Acid

A polyunsaturated long-chain fatty acid with a 16-carbon backbone and exactly 3 double bonds. There are at least 5 separate isomers that…