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HISTOCOMPATIBILITY COMPLEX
| Pronunciation (US): |  | (GB): | |
I. (noun)
Sense 1
Meaning:
A family of fifty or more genes on the sixth human chromosome that code for proteins on the surfaces of cells and that play a role in the immune response
Classified under:
Nouns denoting groupings of people or objects
Hypernyms ("histocompatibility complex" is a kind of...):
category; class; family (a collection of things sharing a common attribute)
Context examples:
This agent lowers plasma cholesterol and lipoprotein levels and modulates immune responses by suppressing MHC II (major histocompatibility complex II) on interferon gamma-stimulated, antigen-presenting cells such as human vascular endothelial cells.
(Atorvastatin, NCI Thesaurus)
KIRs are surface glycoproteins that bind to major histocompatibility complex (MHC)/human leukocyte antigen (HLA) class I subtypes on target cells; binding of KIRs inhibits NK cell-mediated cytotoxicity.
(Anti-KIR Monoclonal Antibody IPH 2101, NCI Thesaurus)
Genetic loci in the vertebrate major histocompatibility complex that encode polymorphic products which control the immune response to specific antigens.
(MHC Class II Gene, NCI Thesaurus)
This agent lowers plasma cholesterol and lipoprotein levels, and modulates immune responses through the suppression of MHC II (major histocompatibility complex II) on interferon gamma-stimulated, antigen-presenting cells such as human vascular endothelial cells.
(Fluvastatin Sodium, NCI Thesaurus)
Increased expression of major histocompatibility complex (MHC) antigens and adhesion molecules leads to enhancement of the recognition of host MHC and/or minor histocompatibility antigens by mature donor T cells.
(Graft-Versus-Host Disease Pathway, NCI Thesaurus/KEGG)
A short chain synthetic antigenic peptide (GILGFVFTL) derived from the influenza virus A matrix protein and presented by HLA-A2 major histocompatibility complex (MHC) class I molecules.
(Flu Matrix Peptide p58-66, NCI Thesaurus)
This agent lowers plasma cholesterol and lipoprotein levels, and modulates immune responses through the suppression of MHC II (major histocompatibility complex II) on interferon gamma-stimulated antigen-presenting cells such as human vascular endothelial cells.
(Fluvastatin, NCI Thesaurus)
IFN-g also mediates interleukin-12 (IL-12) production by antigen-presenting cells (APCs); activates macrophages, cytotoxic T-cells, and natural killer (NK) cells; upregulates major histocompatibility complex (MHC) molecules; and stimulates antibody-dependent cellular cytotoxicity (ADCC).
(Adenovirus-Interferon-Gamma TG1042, NCI Thesaurus)
In turn, the superantigen binds to both major histocompatibility complex class II molecules and to the T-cell receptor beta chain, which results in a massive activation of T lymphocytes and induces a potent T-cell-mediated killing of tumor cells.
(Naptumomab Estafenatox, NCI Thesaurus)
Particularly, reactivation of NO-mediated signaling appears to inhibit the increased tumor cell shedding of the major histocompatibility complex class I chain-related (MIC) molecules MICA and MICB as is seen in hypoxic tumor environments; MIC molecules play key roles in tumor cell immune surveillance through their interaction with the C-type lectin-like NKG2D receptor on natural killer, lymphokine-activated killer and effector T cells.
(Nitroglycerin Transdermal Patch, NCI Thesaurus)
