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Histone deacetylase inhibitor
Pronunciation
Definition 1
A substance that causes a chemical change that stops tumor cells from dividing. Histone deacetylase inhibitors are being studied in the treatment of cancer. Also called HDAC inhibitor. (NCI Dictionary)
Definition 2
Any substance that inhibits histone deacetylase, an enzyme that catalyzes the removal of acetyl groups from core histones. Inhibition of histone deacetylase can result in hyperacetylation of histones, with an effect on gene expression and cell differentiation. (NCI Thesaurus)
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Histone deacetylase 7 (952 aa, ~103 kDa) is encoded by the human HDAC7 gene. This protein is involved in chromatin remodeling. …
Histone deacetylase 6 (1215 aa, ~131 kDa) is encoded by the human HDAC6 gene. This protein plays a role in the unfolded…
Histone deacetylase 5 (1122 aa, ~122 kDa) is encoded by the human HDAC5 gene. This protein is involved in chromatin silencing, transcriptional…
Histone deacetylase 4 (1084 aa, ~119 kDa) is encoded by the human HDAC4 gene. This protein plays a role in the regulation…
Histone deacetylase 3 (428 aa, ~49 kDa) is encoded by the human HDAC3 gene. This protein is involved in the negative regulation…
