Histrelin Acetate

The acetate salt form of histrelin, a long-acting, synthetic nonapeptide analog of gonadotropin-releasing hormone (GnRH) with potential anti-tumor activity. Upon administration, histrelin binds to and activates GnRH receptors; prolonged administration results in pituitary GnRH receptor desensitization and inhibition of follicle stimulating hormone (FSH) and luteinizing hormone (LH) secretion, leading to a significant decline in testosterone production in males and may inhibit androgen receptor-positive tumor progression; in females, prolonged administration results in decreased estradiol production. (NCI Thesaurus)

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History of Sudden Cardiac Death

A first-degree relative (parent, sibling, child) documented to have died suddenly of presumed cardiac etiology without other obvious cause.

History of Resuscitated Cardiac Arrest

An event in the personal medical histroy of cardiac arrest that is reversed, usually by CPR and/or defibrillation or cardioversion, or cardiac…

History of Peripheral Vascular Disease

An event in the personal medical history of peripheral vascular disease as evidenced by: 1. Claudication either with exertion or at rest;…

History of Myocardial Infarction Within 6 Months

An event in a personal medical history indicating that a myocardial infartion has occurred during the previous 6 months.

History of Heart Failure

An event in the personal medical history of heart failure, a condition in which the heart is unable to pump enough blood…

History of Cardiogenic Shock

An event in the personal medical history of sustained, inadequate tissue perfusion secondary to cardiac dysfunction, generally defined as systolic blood pressure…