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HIV Envelope Protein gp120
Definition 1
A protein produced by the human immunodeficiency virus that functions as a viral anti-receptor attachment protein. The protein is localized to the viral envelope and mediates fusion between viral and cellular membranes. (NCI Thesaurus)
Definition 2
External envelope protein of the human immunodeficiency virus which is encoded by the HIV env gene. It has a molecular weight of 120 kD and contains numerous glycosylation sites. Gp120 binds to cells expressing CD4 cell-surface antigens, most notably T4-lymphocytes and monocytes/macrophages. Gp120 has been shown to interfere with the normal function of CD4 and is at least partly responsible for the cytopathic effect of HIV. (NLM, Medical Subject Headings)
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