| Health / Medical Topics |
HLA-A*2402-restricted CDCA1-URLC10-KIF20A-DEPDC1-MPHOSPH1 Multipeptide Vaccine
A cancer vaccine containing five HLA-A*2402-restricted peptide epitopes with potential immunostimulatory and antitumor activities. Peptide epitopes in this vaccine are derived from CDCA1 (cell division cycle-associated protein 1), URLC10 (up-regulated lung cancer 10), KIF20A (kinesin-like family member 20A), DEPDC1 (DEP domain containing 1), and MPHOSPH1 (M phase phosphoprotein 1). Upon administration, this peptide vaccine may stimulate a cytotoxic T lymphocyte (CTL) response against CDCA1-,URLC10-,KIF20A-,DEPDC1-, or MPHOSPH1-expressing tumor cells, resulting in tumor cell lysis and decreased tumor growth. HLA-A*2402 is an MHC class I molecule that presents antigenic peptides to CD8+ T cells; epitope design restricted to epitopes that bind most efficiently to HLA-A*2402 may improve antigenic peptide immunogenicity. (NCI Thesaurus)
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