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HLA Class II Histocompatibility Antigen, DRB1-4 Beta Chain Protein
Definition 1
HLA class II histocompatibility antigen, DRB1-4 beta chain protein (266 aa, ~30 kDa) is encoded by the human HLA-DRB1 gene. This protein is involved in both antigen presentation to regulatory T cells and in the immune response. The antigen is frequently typed for bone marrow and kidney transplantation procedures. (NCI Thesaurus)
Definition 2
A protein on the surface of certain cells that binds another protein called TRAIL, which may kill some cancer cells. An increase in the amount or activity of DR4 on cancer cells may kill more cells. (NCI Dictionary)
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