| Health / Medical Topics |
HMGA1 wt Allele
Human HMGA1 wild-type allele is located within 6p21 and is approximately 9 kb in length. This allele, which encodes high mobility group protein HMG-I/HMG-Y, is involved in chromatin remodeling, DNA-dependent transcriptional regulation and inhibition of tumor suppressor p53 protein-dependent apoptosis. The HMGA1 gene is overexpressed in certain types of cancer including breast carcinoma, colorectal cancer, non-small-cell lung carcinoma, epithelial ovarian carcinoma and thyroid cancer. (NCI Thesaurus)
YOU MAY ALSO LIKE
This gene plays a role in a number of cellular processes including apoptosis, chromatin organization and transcriptional regulation.
A protein that binds to the DNA and certain proteins in chromosomes. It is involved in many functions in the cell, and…
Members of this family of high mobility group (HMG) proteins participate in a wide variety of nuclear processes ranging from chromosome and…
Human HMGA Family Genes encode HMGA proteins that participate in many nuclear processes ranging from chromosome and chromatin mechanics to transcription factors…
A substance that blocks an enzyme needed by the body to make cholesterol and lowers the amount of cholesterol in the…
A rare genetic inherited disorder characterized by inability of the body to process the amino acid leucine. Signs and symptoms include vomiting,…
