HMGN Family Gene

Human HMGN Family Genes encode nuclear HMGN proteins that bind to nucleosomes, change chromatin architecture, and enhance transcription or replication. They typically contain a Nucleosome Binding Domain that anchors these proteins to nucleosome cores to facilitate changes in higher order chromatin structure. HMGN chromatin association is dynamic and regulated by posttranslational modification; related to cell cycle and transcriptional events. (NCI Thesaurus)

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Human HMGB3 wild-type allele is located within Xq28 and is approximately 6 kb in length. This allele, which encodes high mobility group…

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HMGB2 wt Allele

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