| Health / Medical Topics |
Homologous Recombination Pathway
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR. (NCI Thesaurus/KEGG)
YOU MAY ALSO LIKE
The process of exchange of genetic material between autonomous replicons, which depends on regions of extensive sequence homology between the participating DNA…
A protein similar in structure and evolutionary origin to a protein in another species.
A gene from one species which corresponds to a gene in another species and that is related via a common ancestral…
A system provided by the National Center for Biotechnology Information for automated detection of homologs among the annotated genes of several completely…
A drug used to treat certain types of chronic myelogenous leukemia (CML) that have not gotten better after treatment with other…
A region on a chromosome which, when stained, is uniform in appearance. (Normally, a stained chromosome shows a banding pattern.) Homogeneously staining…
