hSWI/SNF

hSWI/SNF is an ATP-dependent chromatin-remodeling complex implicated in the regulation of gene expression, cell cycle control, and oncogenesis. The complex facilitates transcriptional activation of specific genes by antagonizing chromatin-mediated transcriptional repression. Subunits of the complex include: BAF57, BAF60a,-b,-c, BAF155, BAF170, BRG-1, BRM, and hSNF5/INI1. BAF57 contains an HMG domain adjacent to a kinesin-like region and binds DNA. BAF155 and BAF170 are BRG-1-associated proteins with dimerization motifs for transcription factors. BRM and BRG-1 are ATPase subunits of the complex and co-activators for nuclear hormone receptors. BRG-1 interacts with BRCA1, a nuclear phosphoprotein transcription and recombination accessory factor. (NCI Thesaurus)

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