Human Monoclonal Antibody B11-hCG Beta Fusion Protein CDX-1307

A human monoclonal antibody (B11) directed against the mannose receptor and linked to the beta-subunit of human chorionic gonadotropin (hCG beta) with potential immunostimulating and antineoplastic activities. The monoclonal antibody moiety of human monoclonal antibody B11-hCG beta fusion protein CDX-1307 binds to mannose receptors on antigen presenting cells (APCs), including human dendritic cells (DCs) and macrophages. Upon internalization and processing, APCs present the processed hCG beta antigen on their cell surfaces, which may initiate an antibody-dependent cell-mediated cytotoxicity (ADCC) response against hCG beta-expressing tumor cells. The tumor-associated antigen (TAA) hCG beta is selectively overexpressed by a number of tumors including breast, colorectal, pancreatic, bladder and ovarian tumors; its expression may correlate with the stage of disease. (NCI Thesaurus)

YOU MAY ALSO LIKE

Human Monoclonal Antibody 216

A naturally-occurring human IgM monoclonal antibody with potential antineoplastic activity. Human monoclonal antibody 216, derived from the gene VH4-34, binds to the…

Human MOAB LICO 28a32

A human monoclonal immunoglobulin M (IgM) antibody with potential antineoplastic activity. Human MOAB LICO 28a32 binds to the colon tumor-associated antigen…

Human Migration

Movement of residence from one place to another. Includes nomadism; labor or seasonal migration; patterns of rural, urban, or suburban migration; or…

Human MHC Non-Restricted Cytotoxic T-Cell Line TALL-104

An allogeneic human cytotoxic T-lymphocyte cell line (TALL-104) with potential antineoplastic activity. TALL-104 is an IL-2-dependent human leukemic T cell line, expressing…

Human Menopausal Gonadotropin

Follicle-Stimulating Hormone and Luteinizing Hormone excreted in the urine of post-menopausal women.

Human lymphocyte antigen

A type of molecule found on the surface of most cells in the body. Human lymphocyte antigens play an important part in…