Health / Medical Topics |
Hypoxia-Responsive Elements
DNA sequences in a gene's promoter region that mediate expression during hypoxia. Since unlike normal tissues, solid tumors frequently have regions of hypoxia, suicide genes controlled by hypoxia-responsive elements may provide a means for cancer-specific gene therapy. (NCI Thesaurus)
YOU MAY ALSO LIKE
Hypoxia-inducible factor-1 (HIF1) is a transcription factor found in mammalian cells cultured under reduced oxygen tension that plays an essential role in…
Hypoxia (or low O2 levels) affects various pathologies. First, tissue ischemia, a variation in O2 tension caused by hypoxia/reoxygenation, can lead to…
Hypoxia-inducible factor 1-alpha (826 aa, ~93 kDa) is encoded by the human HIF1A gene. This protein plays a role in transcriptional regulation…
A hypoxia-activated prodrug consisting of a 2-nitroimidazole phosphoramidate conjugate with potential antineoplastic activity. The 2-nitroimidazole moiety of hypoxia-activated prodrug TH-302 acts as…
A proprietary, hypoxia-activated prodrug with potential antineoplastic activity. Upon administration, the hypoxia-activated prodrug PR610 is activated in the hypoxic cells within tumors…
Highly expressed in secretory tissues (liver and pancreas) by human HYOU1 Gene (HSP70 Family), hypoxia-induced 999-aa (precursor) 150 kD Hypoxia Up-Regulated 1…