Health / Medical Topics

    I-Kappa-B-Epsilon

    Expressed in spleen, testis, lung, kidney, pancreas, heart, placenta, brain, granulocytes, and macrophages by human NFKBIE Gene (NFKBI), 361-aa 38-kDa cytoplasmic I-Kappa-B-Epsilon contains 6 ANK repeats and preferentially interacts with p65 RELA homodimers and with p65-cRel heterodimers. By complexing with and trapping NF-Kappa-B in the cytoplasm, NFKBIE inhibits and likely regulates NFKB. Serine phosphorylation of NFKBIE results in proteasome-dependent degradation. (NCI Thesaurus)




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