Ibrutinib

Pronunciation

Definition 1

A drug used to treat mantle cell lymphoma in patients who have already received other treatment. It is also being studied in the treatment of other types of cancer. Ibrutinib blocks a protein called Bruton’s tyrosine kinase (BTK), which may help keep cancer cells from growing. It is a type of tyrosine kinase inhibitor. Also called Imbruvica. (NCI Dictionary)

Definition 2

An orally bioavailable, small-molecule inhibitor of Bruton's tyrosine kinase (BTK) with potential antineoplastic activity. Upon oral administration, ibrutinib binds to and irreversibly inhibits BTK activity, thereby preventing both B-cell activation and B-cell-mediated signaling. This leads to an inhibition of the growth of malignant B cells that overexpress BTK. BTK, a member of the src-related BTK/Tec family of cytoplasmic tyrosine kinases, is required for B cell receptor signaling, plays a key role in B-cell maturation, and is overexpressed in a number of B-cell malignancies. The expression of BTK in tumor cells is also associated with increased proliferation and survival. (NCI Thesaurus)

YOU MAY ALSO LIKE

Ibrolipim

A lipoprotein lipase (LPL) activator with antihyperlipidemic activity. Activation of LDL by ibrolipim lowers plasma triglycerides, with a concomitant elevation of high-density…

Ibritumomab tiuxetan

A monoclonal antibody that is used to treat certain types of B-cell non-Hodgkin lymphoma and is being studied in the treatment and…

Ibrance

A drug used to treat hormone-receptor positive (HR+), HER2 negative (HER2-) breast cancer that is advanced or has spread to other parts…

IBMFS

Inherited bone marrow failure syndrome. A rare disorder in which a person’s bone marrow is unable to make enough blood cells and…

Ibizan Hound

The Ibizan Hound is an agile, deer-like, athletic hound that has a long, arched neck, long wedge-shaped head, and very large, triangular…

Ibandronic Acid

A third-generation amino-bisphosphonate with anti-resorptive and anti-hypercalcemic activities. Ibandronic acid binds to and adsorbs onto the surface of hydroxyapatite crystals in the…