| Health / Medical Topics |
IgG Fc Receptor IIA
Expressed in monocytes, macrophages, neutrophils, eosinophils, platelets, NK cells, and T- and B-lymphocytes by human FCGR2A Gene, 281-aa (mature) IgG Fc Receptor IIA is a type I cell surface membrane protein with 2 extracellular IgC2 domains and a low affinity receptor for aggregated IgG Fc region. FCGR2A binding to IgG initiates essential effector and regulatory cellular responses against foreign pathogens and soluble antigens that induce phagocytosis of antigen-antibody complexes, removing them from circulation, and modulate B-cell antibody production. An Arg167His polymorphism affects efficiency of IgG2 recognition. (NCI Thesaurus)
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