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IgG Fc Receptor IIC
Expressed as 4 alternative isoforms in monocytes, macrophages, polymorphonuclear cells, and natural killer cells (Isoform 1) by human FCGR2C Gene, IgG Fc Receptor IIC is a type I cell surface protein with 2 IgC2 domains and a low affinity receptor for aggregated IgG Fc region. FCGR2C binding to IgG initiates essential effector and regulatory cellular responses against foreign pathogens and soluble antigens that induce phagocytosis of antigen-antibody complexes, removing them from circulation, and modulate B-cell antibody production. FCGR2C contains two cytoplasmic ITAM activator motifs involved in cell activation upon receptor aggregation. Isoform 4 may be soluble. (NCI Thesaurus)
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