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IgG Fc Receptor IIIA
Expressed on natural killer cells, macrophages, T cells, immature thymocytes, and trophoblasts by human FCGR3A Gene, 254-aa 29-kDa (precursor) glycosylated IgG Fc Receptor IIIA is a putative type I membrane protein containing 2 IgC2 domains and a receptor for the Fc region of monomeric or aggregated IgG that mediates antibody-dependent responses, such as phagocytosis and antibody-dependent cellular cytotoxicity. FCGR3B exists in a hetero-oligomeric complex with the Fc epsilon receptor I gamma subunit and/or the CD3 zeta subunit, as a soluble receptor produced by proteolytic cleavage. Amino acid conservation between CD16, other Fc receptors, and related Ig suggest similar structures and modes of association. (NCI Thesaurus)
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