IL12B wt Allele

Human IL12B wild-type allele is located within 5q31.1-q33.1 and is approximately 16 kb in length. This allele, which encodes interleukin-12 beta chain protein, plays a role in promoting the growth of both T cells and natural killer cells. It is also involved in the differentiation of both Th1 and Th2 cells. Overexpression of the IL12B gene is associated with multiple sclerosis. A polymorphism in the promoter region of this gene is associated with the severity of both atopic and non-atopic asthma in children. Heritable defects in the IL12B gene are a cause of susceptibility to mycobacterial disease. (NCI Thesaurus)

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IL12B Gene

This gene is involved in immunity/defense via the stimulation of both T cells and natural killer cells. It also plays a role…

IL12A wt Allele

Human IL12A wild-type allele is located within 3p12-q13.2 and is approximately 7 kb in length. This allele, which encodes interleukin-12 alpha chain…

IL12A Gene

This gene plays a role in immunity/defense via the stimulation of both T cells and natural killer cells. It is also involved…

IL12 Signaling Pathway

Interleukin-12 (IL-12) promotes cell-mediated immunity by inducing Th1 cell differentiation and activation of both T cells and NK cells. Dendritic cells…

IL11RA wt Allele

Human IL11RA wild-type allele is located in the vicinity of 9p13.3 and is approximately 11 kb in length. This allele, which encodes…

IL11RA Gene

This gene is involved in interleukin 11 receptor mediation and signal transduction.