IL12RB1 wt Allele

Human IL12RB1 wild-type allele is located in the vicinity of 19p13.1 and is approximately 74 kb in length. This allele, which encodes interleukin-12 receptor beta-1 chain protein, is involved in IL12 signal transduction. Heritable defects in the IL12RB1 gene are a cause of susceptibility to mycobacterial disease. (NCI Thesaurus)

YOU MAY ALSO LIKE

IL12RB1 Gene

This gene plays a role in cellular signaling and is involved in immunity/defense.

IL12B wt Allele

Human IL12B wild-type allele is located within 5q31.1-q33.1 and is approximately 16 kb in length. This allele, which encodes interleukin-12 beta chain…

IL12B Gene

This gene is involved in immunity/defense via the stimulation of both T cells and natural killer cells. It also plays a role…

IL12A wt Allele

Human IL12A wild-type allele is located within 3p12-q13.2 and is approximately 7 kb in length. This allele, which encodes interleukin-12 alpha chain…

IL12A Gene

This gene plays a role in immunity/defense via the stimulation of both T cells and natural killer cells. It is also involved…

IL12 Signaling Pathway

Interleukin-12 (IL-12) promotes cell-mediated immunity by inducing Th1 cell differentiation and activation of both T cells and NK cells. Dendritic cells…