IL17 Signaling Pathway

Inflammation is a complex response involving many different cells and signaling molecules, including the secretion of the cytokine IL-17 by activated T cells. IL-17 secretion is restricted to specific subsets of T cells but the receptor for IL-17 is widely expressed throughout the body, including fibroblasts and epithelial cells. Inflammatory responses involving IL-17 probably contribute to arthritis, asthma, skin immune reactions, and autoimmune disorders. Fibroblasts and other cells stimulated by IL-17 are induced themselves to secrete inflammatory and hematopoietic cytokines, including IL-6, IL-8, G-CSF, and Stem Cell Factor (SCF). These cytokines in turn provoke a range of activities, including the stimulation of neutrophil proliferation and differentiation. (NCI Thesaurus/BIOCARTA)

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IL17 Gene

This gene is involved in the regulation of osteoclastogenesis and plays a role in rheumatoid arthritis.

IL16 wt Allele

Human IL16 wild-type allele is located in the vicinity of 15q26.3 and is approximately 130 kb in length. This allele, which encodes…

IL16 Gene

This gene is involved in chemotaxis and is a pro-inflammatory factor.

IL15 wt Allele

Human IL15 wild-type allele is located within 4q31 and is approximately 97 kb in length. This allele, which encodes interleukin-15 protein, plays…

IL15 Gene

This gene is involved in the regulation of memory T cells and cytokine production.

IL14 Gene

Human IL14 gene at 5q31 encodes Interleukin-14, which is a cytokine that induces B-cell proliferation, inhibits immunoglobulin secretion, and selectively expands certain…