IL18 Signaling Pathway

IL-18 is a pro-inflammatory cytokine similar in structure and mechanism of action to IL-1 beta. Formation of active IL-18 by macrophages requires cleavage of an inactive precursor by caspase-1 protease, also termed the IL-1 converting enzyme (ICE). One of the key biological responses induced by IL-18 is that, in combination with IL-12, it stimulates Th1 cell differentiation and involvement in immune responses. IL-18 was originally known as interferon-gamma-inducing factor, named after its induction of interferon-gamma production. Up-regulation of Fas ligand in Th1 cells by IL-18 may increase apoptosis of Fas receptor expressing cells that interact with the activated Th1 cells. This induction of apoptosis may allow IL-18 to have anti-tumor activity and may also play a role in chronic inflammatory and autoimmune conditions. (NCI Thesaurus/BIOCARTA)

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IL18 Gene

This gene is involved in the induction and regulation of pro-inflammatory cytokines.

IL17RB wt Allele

Human IL17RB wild-type allele is located in the vicinity of 3p21.1 and is approximately 19 kb in length. This allele, which encodes…

IL17RB Gene

This gene plays a role in both cytokine binding and signaling.

IL17C wt Allele

Human IL17C wild-type allele is located within 16q24 and is approximately 2 kb in length. This allele, which encodes interleukin-17C protein, is…

IL17C Gene

This gene plays a role in inflammatory processes and modulates cytokine activity.

IL17 wt Allele

Human IL17 wild-type allele is located within 6p12 and is approximately 4 kb in length. This allele, which encodes interleukin-17 protein, plays…