Health / Medical Topics |
IL21R/BCL6 Fusion Gene
A fusion gene that results from a chromosomal translocation t(3;16)(q27;p11) which fuses the promoter region of the IL21R gene near the 5' end of the BCL6 gene. This rearrangement is associated with aberrant expression of the BCL6 gene product and diffuse large B-cell lymphoma. (NCI Thesaurus)
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Human IL21 wild-type allele is located within 4q26-q27 and is approximately 8 kb in length. This allele, which encodes interleukin-21 protein, is…
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This gene is involved in cytokine signaling.