IL22 Signaling Pathway

IL-22 is an inflammatory cytokine related to IL-10 that is produced by T cells and that induces a response in cells through a heterodimeric cell surface receptor composed of IL-22R1 and IL-10R2C. One of the actions of IL-22 appears to be the induction of acute phase inflammatory response in hepatocytes, acting through activation of STATs and transcriptional regulation. A gene with homology to the extracellular domain of the cell surface IL-22R1 receptor component was identified that lacked transmembrane and cytoplasmic domains. The protein derived from this gene was found to bind IL-22 and block its interaction with the cell surface receptor. The IL-22 soluble receptor (IL-22BP, IL-22 binding protein) also blocks some of the downstream effects of IL-22 such as STAT activation and the transcriptional induction of genes involved in the immune and inflammatory responses. The IL-22 soluble receptor may act as an anti-inflammatory agent. (NCI Thesaurus/BIOCARTA)

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IL22 Gene

This gene is involved in the immune response.

IL21R/BCL6 Fusion Gene

A fusion gene that results from a chromosomal translocation t(3;16)(q27;p11) which fuses the promoter region of the IL21R gene near the 5'…

IL21R wt Allele

Human IL21R wild-type allele is located in the vicinity of 16p11 and is approximately 48 kb in length. This allele, which encodes…

IL21R Gene

This gene is involved in cytokine recognition.

IL21 wt Allele

Human IL21 wild-type allele is located within 4q26-q27 and is approximately 8 kb in length. This allele, which encodes interleukin-21 protein, is…

IL21 Gene

This gene plays a role in both cytokine signaling and immune responses.